- Title
- Understanding Food Allergy Through Neuroimmune Interactions in the Gastrointestinal Tract
- Creator
- Burns, Grace L.; Keely, Simon
- Relation
- NHMRC.APP1128487 http://purl.org/au-research/grants/nhmrc/1128487
- Relation
- Annals of Allergy, Asthma & Immunology Vol. 131, Issue 5, p. 576-584
- Publisher Link
- http://dx.doi.org/10.1016/j.anai.2023.06.015
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2023
- Description
- Food allergies are adverse immune reactions to food proteins in the absence of oral tolerance and the incidence of allergies to food including peanut, cow's milk and shellfish has been increasing globally. While advancements have been made towards understanding the contributions of the type 2 immune response to allergic sensitisation, crosstalk between these immune cells and neurons of the enteric nervous system is an area of emerging interest in the pathophysiology of food allergy, given the close proximity of neuronal cells of the enteric nervous system and type 2 effector cells including eosinophils and mast cells. At mucosal sites, such as the gastrointestinal tract, neuroimmune interactions contribute to the sensing and response to danger signals from the epithelial barrier. This communication is bi-directional, as immune cells express receptors for neuropeptides and transmitters, and neurons express cytokine receptors, allowing for the detection of and response to inflammatory insults. In addition, it appears neuromodulation of immune cells including mast cells, eosinophils and innate lymphoid cells is critical for amplification of the type 2 allergic immune response. As such, neuroimmune interactions may be critical targets for future food allergy therapies. This review examines the contributions of local enteric neuroimmune interactions to the underlying immune response in food allergy and discusses considerations for future investigations into targeting neuroimmune pathways for treatment of food allergies.
- Subject
- food allergy; immune; cells; nervous system; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1493291
- Identifier
- uon:53532
- Identifier
- ISSN:1081-1206
- Language
- eng
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